on Writers Helping Writers:

In story terms, a villain is a person, entity, or force who is cruel, evil, or malicious enough to wish the protagonist harm. Rather than simply blocking a goal or interfering with the hero’s plan, a villain causes suffering, making it vital for them to be conquered by the protagonist. Clarice must find and defeat Buffalo Bill if she wants to rise above her past and become a great FBI agent (The Silence of the Lambs); Chief Brody must kill the man-eating shark to preserve his town (Jaws).
Regardless of the form your villain takes, there are certain qualities that will make them formidable and credible—qualities and connections they share with the protagonist. Let’s explore these qualifications through a case study of Dr. Lawrence Myrick, played by Gene Hackman in the movie Extreme Measures.